Squamous Cell Carcinoma of the Caruncle

• Published in: Ophthalmic plastic and reconstructive surgery Vol. 31; no. 4; p. e80
• Main Authors: Sagili, Suresh, Yin, Vivian, Esmaeli, Bita, O'Donnell, Brett, Eckstein, Robert, Malhotra, Raman
• Format: Journal Article
• Language: English
• Published: United States 01.07.2015
• Subjects: Aged; Antimetabolites, Antineoplastic - therapeutic use; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - therapy; Chemotherapy, Adjuvant; Combined Modality Therapy; Conjunctiva - surgery; Conjunctival Neoplasms - secondary; Conjunctival Neoplasms - therapy; Eyelid Neoplasms - pathology; Eyelid Neoplasms - therapy; Female; Fluorouracil - therapeutic use; Humans; Lymphatic Metastasis; Male; Middle Aged; Mitomycin - therapeutic use; Ophthalmologic Surgical Procedures; Submandibular Gland Neoplasms - secondary; Submandibular Gland Neoplasms - therapy
• DOI: 10.1097/IOP.0000000000000108

Squamous cell carcinoma (SCC) of the lacrimal caruncle is a rare entity. The authors report the management and outcomes of 3 cases of caruncle SCC. Case 1 underwent wide margin surgical excision with adjuvant topical chemotherapy for a poorly differentiated SCC. He later developed regional lymph node metastasis and required modified radical neck dissection. Case 2 underwent wide margin surgical excision with cryotherapy and adjuvant topical chemotherapy for an invasive moderately differentiated SCC. She later developed a recurrence and underwent orbital exenteration. Case 3 was a moderately differentiated SCC treated with wide margin excision alone and had no recurrence during 5-year follow up. Careful surveillance of caruncle SCC is required, given the observed propensity for local recurrence and/or regional metastasis.