Role of DNA-dependent protein kinase in the HIV-1 replication cycle

• Published in: Molecular Biology Vol. 50; no. 4; pp. 567 - 579
• Main Authors: Knyazhanskaya, E. S., Shadrina, O. A., Anisenko, A. N., Gottikh, M. B.
• Format: Journal Article Book Review
• Language: English
• Published: Moscow Pleiades Publishing 01.07.2016; Springer Nature B.V
• Subjects: Biochemistry; Biology; Biomedical and Life Sciences; Deoxyribonucleic acid; DNA; DNA-dependent protein kinase; Genomes; HIV; Human Genetics; Human immunodeficiency virus; Human immunodeficiency virus 1; Lentivirus; Life cycles; Life Sciences; Proteins; Replication; Retroviridae; Reviews; Viruses; HIV-1; Ku70; retrovirus integration; Ku80; retrovirus transcription; DNA-PK

Human immunodeficiency virus type 1 (HIV-1) is among the best-studied viruses, but some aspects of HIV-1 biology remain obscure. The role of cell proteins in virus replication raises especially many questions. One of the proteins is DNA-dependent protein kinase (DNA-PK), which performs crucially imp...