Transdermal absorption of fentanyl and sufentanil in man

• Published in: European journal of clinical pharmacology Vol. 32; no. 5; p. 529
• Main Authors: Sebel, P S, Barrett, C W, Kirk, C J, Heykants, J
• Format: Journal Article
• Language: English
• Published: Germany 01.01.1987
• Subjects: Administration, Cutaneous; Female; Fentanyl - analogs & derivatives; Fentanyl - metabolism; Humans; Male; Skin Absorption; Sufentanil

We have studied the transdermal absorption of tritiated fentanyl (citrate and base) and sufentanil citrate. Approximately 50 micrograms of drug in water was applied to the forearm skin of volunteers (5 subjects for fentanyl citrate and base, 6 for sufentanil). When the water had evaporated the site...