Serum inflammatory markers and clinical/MRI markers of disease progression in multiple sclerosis

• Published in: Journal of neurology Vol. 248; no. 6; pp. 487 - 495
• Main Authors: GIOVANNONI, G, MILLER, D. H, LOSSEFF, N. A, SAILER, M, LEWELLYN-SMITH, N, THOMPSON, A. J, THOMPSON, E. J
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.06.2001; Springer Nature B.V
• Subjects: Adult; Atrophy; Axons - pathology; Biological and medical sciences; Biomarkers - analysis; C-Reactive Protein - analysis; Disease Progression; Female; Humans; Immunology; Inflammation; Inflammation - physiopathology; Intercellular Adhesion Molecule-1 - blood; Magnetic Resonance Imaging; Male; Medical sciences; Metabolites; Middle Aged; Multiple sclerosis; Multiple Sclerosis - pathology; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Nitric oxide; Nitric Oxide - blood; Pathogenesis; Patients; Recurrence; Tumor Necrosis Factor-alpha - analysis; Tumor necrosis factor-TNF; Vascular Cell Adhesion Molecule-1 - blood; Human; Nervous system diseases; Vascular cell adhesion molecule 1; Multiple sclerosis; Prognosis; Intercellular adhesion molecule 1; Cytokine; Exploration; Inflammation; Nuclear magnetic resonance imaging; Inflammatory disease; Atrophy; Nitric oxide; Central nervous system disease; Medical imagery; Serum; Predictive factor; C reactive protein; Tumor necrosis factor α; Brain (vertebrata)

The aim of this study was to assess whether mean serum levels of inflammatory markers when measured serially correlate with disease progression or putative MRI markers of axonal loss in a cohort of well-characterised multiple sclerosis (MS) patients. Serial serum levels of soluble vascular cell adhe...