GSK3-Driven Modulation of Inflammation and Tissue Integrity in the Animal Model

• Published in: International journal of molecular sciences Vol. 25; no. 15; p. 8263
• Main Authors: Kühl, Friederike, Brand, Korbinian, Lichtinghagen, Ralf, Huber, René
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2024
• Subjects: animal models; Animals; Arthritis; Atherosclerosis; Cardiomyocytes; Cell death; Disease Models, Animal; Enzymes; Fertility; Glycogen Synthase Kinase 3 - genetics; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta - metabolism; GSK3α; GSK3β; Humans; Immune response; Infertility; Inflammation; Inflammation - metabolism; Inflammation - pathology; inflammatory diseases; Kinases; Metabolism; Methylene blue; Phosphorylation; Proteins; serine/threonine phosphorylation; Serotonin; GSK3β; inflammatory diseases; GSK3α; animal models; serine/threonine phosphorylation; inflammation

Nowadays, GSK3 is accepted as an enzyme strongly involved in the regulation of inflammation by balancing the pro- and anti-inflammatory responses of cells and organisms, thus influencing the initiation, progression, and resolution of inflammatory processes at multiple levels. Disturbances within its...