The Ala16Val MnSOD gene polymorphism modulates oxidative response to exercise

• Published in: Clinical biochemistry Vol. 46; no. 4-5; pp. 335 - 340
• Main Authors: Bresciani, Guilherme, González-Gallego, Javier, da Cruz, Ivana B., de Paz, Jose A., Cuevas, María J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2013
• Subjects: Adolescent; Amino Acid Substitution; Enzyme activity; Gene expression; Gene Expression Regulation, Enzymologic; Gene Frequency; Gene-Environment Interaction; Genetic Association Studies; Glutathione - blood; Heart Rate; Humans; Male; Mitochondria - enzymology; MnSOD polymorphism; Oxidation-Reduction; Oxidative Stress - genetics; Oxygen Consumption; Physical exercise; Physical Exertion; Polymorphism, Single Nucleotide; Redox balance; RNA, Messenger - genetics; RNA, Messenger - metabolism; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Young Adult; Physical exercise; Redox balance; Enzyme activity; Gene expression; MnSOD polymorphism

In humans, the manganese-superoxide dismutase (MnSOD) gene contains a polymorphism (Ala16Val) that has been related to several metabolic dysfunctions and chronic diseases. However, the obtained results suggest that risks related to this polymorphism are directly influenced by environmental factors....