Polymorphism of an Nα-Aroyl-N-Aryl-Phenylalanine Amide: An X-ray and Electron Diffraction Study

• Published in: MolBank Vol. 2024; no. 3; p. M1851
• Main Authors: Lang, Markus, Goddard, Richard, Patzer, Michael, Ganapathy, Uday S., Dick, Thomas, Richter, Adrian, Seidel, Rüdiger W.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2024
• Subjects: Amides; amino acids; Analysis; antibiotics; Aromatic compounds; Asymmetry; Chemical synthesis; Coupling (molecular); Cyano groups; Diffraction; drug discovery; Electron diffraction; Hydrogen bonds; Identification and classification; Lead compounds; Methods; Molecular structure; mycobacteria; Phenylalanine; Polymorphism; Polymorphism (Crystallography); Properties; Protons; Racemization; RNA polymerase; Structure; Symmetry; Tuberculosis; X-rays; Germany

In view of the rise of drug-resistant tuberculosis and difficult-to-treat related diseases caused by non-tuberculous mycobacteria, there is an urgent need for antimycobacterial drug discovery. Nα-aroyl-N-aryl-phenylalanine amides (AAPs) have been identified as antimycobacterial agents and are subjec...