A novel role for an insect apolipoprotein (apolipophorin III) in beta-1,3-glucan pattern recognition and cellular encapsulation reactions

• Published in: The Journal of immunology (1950) Vol. 172; no. 4; pp. 2177 - 2185
• Main Authors: Whitten, Miranda M A, Tew, Ian F, Lee, Bok L, Ratcliffe, Norman A
• Format: Journal Article
• Language: English
• Published: United States 15.02.2004
• Subjects: Amino Acid Sequence; Animals; apolipophorin III; Apolipoproteins - metabolism; Apolipoproteins - pharmacology; Apolipoproteins - physiology; beta-Glucans; Cell Adhesion - drug effects; Cell Adhesion - immunology; Cell Movement - drug effects; Cell Movement - immunology; Dimyristoylphosphatidylcholine - pharmacology; Galleria mellonella; Glucans - metabolism; Hemocytes - cytology; Hemocytes - drug effects; Hemocytes - immunology; Hemocytes - microbiology; Hypocreales - metabolism; Immunity, Innate; Insect Proteins - metabolism; Insect Proteins - pharmacology; Insect Proteins - physiology; Larva - cytology; Larva - immunology; Larva - metabolism; Larva - microbiology; Microspheres; Molecular Sequence Data; Moths - cytology; Moths - immunology; Moths - metabolism; Moths - microbiology; Protein Binding - immunology; Spores, Fungal - metabolism

Lipoproteins and molecules for pattern recognition are centrally important in the innate immune response of both vertebrates and invertebrates. Mammalian apolipoproteins such as apolipoprotein E (apoE) are involved in LPS detoxification, phagocytosis, and possibly pattern recognition. The multifunct...