Biomarkers for the early stages of clinical development in Alzheimer's disease

• Published in: Therapie Vol. 65; no. 4; p. 285
• Main Authors: Bordet, Régis, Dartigues, Jean-François, Dubois, Bruno, Goehrs, Jean-Marie, Vernoux, Laura, Semah, Franck, Pasquier, Florence, Bidaut-Mazel, Claude
• Format: Journal Article
• Language: English
• Published: France 01.07.2010
• Subjects: Age of Onset; Aged; Alzheimer Disease - diagnosis; Alzheimer Disease - drug therapy; Alzheimer Disease - psychology; Biomarkers; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Progression; Humans; Middle Aged; Nootropic Agents - therapeutic use

As the failure of several recent Phase III drug development programmes bears witness, the clinical development of "disease-modifying" drugs in Alzheimer's disease has been confronted with challenging methodological difficulties. Taking into account the financial stakes involved taking...