Phenotypic Modulation of the Mesangium Reflected by Contractile Proteins in Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 45; no. 4; pp. 488 - 495
• Main Authors: Makino, Hirofumi, Kashihara, Naoki, Sugiyama, Hitoshi, Kanao, Koichiro, Sekikawa, Takashi, Okamoto, Kazunori, Maeshima, Yohei, Ota, Zensuke, Nagai, Ryozo
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.04.1996
• Subjects: Actins - analysis; Actins - biosynthesis; Adult; Aged; Animals; Antibodies; Associated diseases and complications; Biological and medical sciences; Blood Glucose - metabolism; Calmodulin-Binding Proteins - analysis; Calmodulin-Binding Proteins - biosynthesis; Contractile Proteins - analysis; Contractile Proteins - biosynthesis; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Diabetes. Impaired glucose tolerance; Diabetic nephropathies; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; DNA, Complementary; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Gene Expression; Genetic aspects; Glomerular Mesangium - metabolism; Glomerular Mesangium - pathology; Glomerular Mesangium - physiopathology; Humans; Immunohistochemistry; Male; Medical sciences; Middle Aged; Myosin Heavy Chains - analysis; Myosin Heavy Chains - biosynthesis; Phenotype; Protein biosynthesis; Protein synthesis; Proteins; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger - analysis; RNA, Messenger - biosynthesis; Synthesis; Endocrinopathy; Molecular form; Urinary system disease; Rat; Mesangial cell; Diabetes mellitus; Rodentia; Biological marker; Contractile protein; Renal disease; Vertebrata; Phenotype; Mammalia; Nephropathy; Animal

The phenotypic change of the mesangial cell is considered to play a pivotal role in the accumulation of extracellular matrix in diabetic nephropathy. This investigation was undertaken to evaluate the expression of the various isoforms of contractile proteins in the streptozocin (STZ)-induced diabeti...