Regulation of ERα Protein Expression by 17β-Estradiol in Cultured Neurons of Hypothalamic Ventromedial Nucleus

• Published in: Neurochemical research Vol. 38; no. 1; pp. 82 - 89
• Main Authors: Malikov, V., Madeira, M. D.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 2013
• Subjects: 17 beta -Estradiol; Animals; Antibody Specificity; Biochemistry; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Cell Biology; Cells, Cultured; Culture Media; Estradiol - pharmacology; Estrogen Receptor alpha - biosynthesis; Estrogen Receptor beta - biosynthesis; Female; Immunohistochemistry; Neurochemistry; Neurology; Neurons - drug effects; Neurons - metabolism; Neurosciences; Original Paper; Ovariectomy; Progesterone - pharmacology; Rats; Rats, Wistar; Ventromedial Hypothalamic Nucleus - cytology; Ventromedial Hypothalamic Nucleus - metabolism; 17β-Estradiol; Estrogen receptor alpha; Cultured hypothalamic neurons; Ventromedial nucleus

The activation of the subtype α of estrogen receptors (ERα) in the hypothalamic ventromedial nucleus (VMNvl) is required to stimulate female sexual receptivity. Moreover, the hormone was found to govern the expression of the receptor. Its removal due to ovariectomy and subsequent substitution sugges...