Mesenchymal Stem Cell-Based Cartilage Regeneration Approach and Cell Senescence: Can We Manipulate Cell Aging and Function?

• Published in: Tissue engineering. Part B, Reviews Vol. 23; no. 6; pp. 529 - 539
• Main Authors: Szychlinska, Marta A., Stoddart, Martin J., D'Amora, Ugo, Ambrosio, Luigi, Alini, Mauro, Musumeci, Giuseppe
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.12.2017
• Subjects: Aging; Animals; Arthritis; Biomechanics; Biomedical materials; Bone marrow; Cartilage; Cartilage diseases; Cartilage, Articular - cytology; Cartilage, Articular - physiology; Cell Differentiation; Cells; Cellular Senescence; Chondrocytes; Chondrogenesis; Chronic illnesses; Collagen; Councils; Deoxyribonucleic acid; Disease; DNA; DNA methylation; Epigenetics; Gene expression; Genetic engineering; Genotype & phenotype; Histology; Homeostasis; Humans; Mechanical stimuli; Mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Mesenchyme; Metabolism; Older people; Osteoarthritis; Regeneration; Review Articles; Senescence; Telomerase; Tissue Engineering; Italy; Switzerland; TGF-β/Smad; mesenchymal stem cells; telomere shortening; aging; cellular therapy; mechanical stimulation; telomerase activators; epigenetics; cell senescence

Aging is the most prominent risk factor triggering several degenerative diseases, such as osteoarthritis (OA). Due to its poor self-healing capacity, once injured cartilage needs to be reestablished. This process might be approached through resorting to cell-based therapies and/or tissue engineering...