Developmental Exposure to Very Low Levels of Ethynilestradiol Affects Anxiety in a Novelty Place Preference Test of Juvenile Rats

• Published in: Neurotoxicity research Vol. 30; no. 4; pp. 553 - 562
• Main Authors: Zaccaroni, Marco, Seta, Daniele Della, Farabollini, Francesca, Fusani, Leonida, Dessì-Fulgheri, Francesco
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2016
• Subjects: Analysis of Variance; Animals; Anxiety - chemically induced; Biomedical and Life Sciences; Biomedicine; Cell Biology; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Exposure; Ethinyl Estradiol - toxicity; Female; Male; Motor Activity - drug effects; Neurobiology; Neurochemistry; Neurology; Neurosciences; Original Article; Pharmacology/Toxicology; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Recognition (Psychology); Spatial Behavior - drug effects; Endocrine disruptors; 17α-ethynilestradiol; Xenoestrogens; Exploratory behavior; Estrogen; Anxiety; 17β-estradiol; Neophobia; Contraceptive pill; Developmental windows; Novelty

Ethinylestradiol (EE 2 ), a synthetic mimic of 17β-estradiol, is widespread in the environment because of its use as a contraceptive. In mammals, recent research highlighted behavioral, physiological, and morphological effects of exposition to EE 2 (this xenoestrogen). We studied if developmental ex...