Correlation of Pituitary Histomorphometry with Adrenocorticotrophic Hormone Response to Domperidone Administration in the Diagnosis of Equine Pituitary Pars Intermedia Dysfunction

• Published in: Veterinary pathology Vol. 45; no. 1; pp. 26 - 38
• Main Authors: Miller, M.A, Pardo, I.D, Jackson, L.P, Moore, G.E, Sojka, J.E
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA American College of Veterinary Pathologists 2008; SAGE Publications
• Subjects: adenoma; Adrenocorticotropic Hormone - metabolism; Animals; antagonists; benzimidazoles; corticotropin; disease diagnosis; Domperidone; Dopamine Antagonists; dopamine receptor antagonists; dopaminergic inhibition; endocrine diseases; Female; hormone secretion; Horse Diseases - diagnosis; Horse Diseases - metabolism; Horses; hyperplasia; hypertrophy; Male; morphometry; Organ Size; Pituitary Diseases - diagnosis; Pituitary Diseases - metabolism; Pituitary Diseases - veterinary; pituitary gland; Pituitary Gland, Intermediate - metabolism; Pituitary Gland, Intermediate - pathology; histomorphometry; pituitary adenoma; pituitary hyperplasia; pituitary pars intermedia dysfunction; dopaminergic inhibition; ACTH; adrenocorticotrophic hormone; domperidone; equine; horses

Functional evaluation of the pars intermedia (PI) is required for the early diagnosis of equine pituitary PI dysfunction (PPID), yet most assays target the hypothalamic-pituitary-adrenal axis, which regulates the pars anterior. In contrast, the PI is regulated by dopaminergic tone from hypothalamic...