N-terminal and C-terminal fragments of IGFBP-4 as novel biomarkers for short-term risk assessment of major adverse cardiac events in patients presenting with ischemia

• Published in: Clinical biochemistry Vol. 45; no. 7-8; pp. 519 - 524
• Main Authors: Postnikov, A.B., Smolyanova, T.I., Kharitonov, A.V., Serebryanaya, D.V., Kozlovsky, S.V., Tryshina, Y.A., Malanicev, R.V., Arutyunov, A.G., Murakami, M.M., Apple, F.S., Katrukha, A.G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2012
• Subjects: Acute coronary syndrome; Aged; Aged, 80 and over; Amino Acid Sequence; Animals; Area Under Curve; Biomarkers; Biomarkers - blood; Cardiovascular risk; Coronary Artery Bypass; Cross Reactions; Female; HEK293 Cells; Humans; IGFBP-4 fragments; Immunoassay; Insulin-Like Growth Factor Binding Protein 4 - blood; Ischemia; Major adverse cardiac events (MACE); Male; Mice; Mice, Inbred BALB C; Middle Aged; Molecular Sequence Data; Myocardial infarction; Myocardial Ischemia - diagnosis; Myocardial Ischemia - pathology; Peptide Fragments - blood; Plaque, Atherosclerotic - metabolism; Pregnancy Associated Plasma Protein A (PAPP-A); Pregnancy-Associated Plasma Protein-A - analysis; Prognosis; Proportional Hazards Models; Prospective Studies; Proteolysis; Risk Assessment; Risk Factors; ROC Curve; Sensitivity and Specificity; Time Factors; Myocardial infarction; Immunoassay; Prognosis; Ischemia; Cardiovascular risk; Biomarkers; IGFBP-4 fragments; Major adverse cardiac events (MACE); Acute coronary syndrome; Pregnancy Associated Plasma Protein A (PAPP-A)

Pregnancy Associated Plasma Protein A (PAPP-A)-derived N- and C-terminal fragments of IGF-binding protein-4 (NT- and CT-IGFBP-4) released from vulnerable atherosclerotic plaques are proposed to be used for cardiovascular risk assessment. NT- and CT-IGFBP-4 were measured by novel immunoassays in EDTA...