Beyond the Dopamine Receptor: the DARPP-32/Protein Phosphatase-1 Cascade

• Published in: Neuron Vol. 23; no. 3; pp. 435 - 447
• Main Authors: Greengard, Paul, Allen, Patrick B., Nairn, Angus C.
• Format: Book Review Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.1999
• Subjects: Animals; Brain - enzymology; Brain Chemistry - physiology; DARPP-32 protein; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors - metabolism; Nerve Tissue Proteins - physiology; nigrostriatum; Phosphoprotein Phosphatases - physiology; Phosphoproteins; Protein Phosphatase 1; Receptors, Dopamine - physiology

Of the many slow-acting neurotransmitters utilized by the mammalian central nervous system, dopamine has received by far the most attention. There are major medical reasons for this interest in understanding the nature of dopaminergic neurotransmission. Parkinson's disease is attributable to a...