Meta-Analysis of the Input and Disposition of Various Dosage Forms of Methylprednisolone in Healthy Subjects Utilizing a Physiologically Based Pharmacokinetic Model

• Published in: The AAPS journal Vol. 27; no. 1; p. 24
• Main Authors: Yu, Ruihong, Jusko, William J.
• Format: Journal Article
• Language: English
• Published: United States Springer 09.01.2025
• Subjects: Administration, Oral; Analysis; Biological Availability; Corticosteroids; Esters; Generic drugs; Half-Life; Healthy Volunteers; Humans; Injections, Intramuscular; Liver; Methylprednisolone; Methylprednisolone - administration & dosage; Methylprednisolone - pharmacokinetics; Models, Biological; Phosphates; Tissue Distribution; methylprednisolone; pharmacokinetics; prodrug conversion; minimal physiologically based pharmacokinetic model (mPBPK model); human

The study quantitatively analyzes and compares the pharmacokinetics (PK) of methylprednisolone (MPL) in humans upon administration of various dosage forms. The PK parameters and profiles of MPL in healthy subjects were collected from 22 literature sources. A minimal physiologically based pharmacokin...