Electroporation-based technologies for medicine: principles, applications, and challenges

• Published in: Annual review of biomedical engineering Vol. 16; p. 295
• Main Authors: Yarmush, Martin L, Golberg, Alexander, Serša, Gregor, Kotnik, Tadej, Miklavčič, Damijan
• Format: Journal Article
• Language: English
• Published: United States 11.07.2014
• Subjects: Administration, Cutaneous; Animals; Biomedical Engineering - methods; Cell Membrane - physiology; Cell Membrane Permeability; Drug Delivery Systems; Electric Impedance; Electrochemotherapy; Electromagnetic Fields; Electroporation - methods; Humans; Neoplasm Metastasis; Neoplasms - therapy; Permeability; Positron-Emission Tomography; RNA, Small Interfering - metabolism; Thermodynamics; Tissue Engineering - methods; Tomography, X-Ray Computed; Ultrasonography; electrochemotherapy; gene electrotransfer; pulsed electric field; DNA vaccination; electropermeabilization; irreversible electroporation

When high-amplitude, short-duration pulsed electric fields are applied to cells and tissues, the permeability of the cell membranes and tissue is increased. This increase in permeability is currently explained by the temporary appearance of aqueous pores within the cell membrane, a phenomenon termed...