Human Rhinovirus Infection Induces Airway Epithelial Cell Production of Human β-Defensin 2 Both In Vitro and In Vivo

• Published in: The Journal of immunology (1950) Vol. 172; no. 7; pp. 4637 - 4645
• Main Authors: Proud, David, Sanders, Scherer P, Wiehler, Shahina
• Format: Journal Article
• Language: English
• Published: United States 01.04.2004
• Subjects: Adult; beta-Defensins - biosynthesis; beta-Defensins - genetics; beta-Defensins - metabolism; Cell Line, Tumor; Common Cold - immunology; Common Cold - metabolism; Common Cold - virology; Female; Human rhinovirus; Humans; Interleukin-1 - physiology; Male; NF-kappa B - physiology; Promoter Regions, Genetic - immunology; Respiratory Mucosa - cytology; Respiratory Mucosa - immunology; Respiratory Mucosa - metabolism; Respiratory Mucosa - virology; Rhinovirus - classification; Rhinovirus - immunology; Rhinovirus - physiology; RNA, Messenger - biosynthesis; RNA, Messenger - metabolism; RNA, Viral - biosynthesis; Serotyping - classification; Time Factors; Virus Inactivation; Virus Replication - immunology

We hypothesized that airway epithelial cells, the primary site of human rhinovirus (HRV) infection, provide a link between the innate and specific immune response to HRV via production of human β-defensin (HBD)-2, a potent in vitro attractant and activator of immature dendritic cells. Infection of p...