The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins

• Published in: Journal of ethnopharmacology Vol. 147; no. 1; pp. 232 - 237
• Main Authors: O׳Neill, Taryn, Johnson, John A., Webster, Duncan, Gray, Christopher A.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 02.05.2013
• Subjects: (3R8S)-falcarindiol; antibacterial properties; Antimycobacterial activity; Antitubercular Agents - chemistry; Antitubercular Agents - isolation & purification; Antitubercular Agents - pharmacology; bergapten; bioassays; Biological Assay; C-17 diynes; Canada; Chemical Fractionation; Diynes - chemistry; Diynes - isolation & purification; Diynes - pharmacology; First Nations; Fluorometry; Furanocoumarins; Furocoumarins - chemistry; Furocoumarins - isolation & purification; Furocoumarins - pharmacology; Heracleum; Heracleum - chemistry; Heracleum maximum; Magnetic Resonance Spectroscopy; medicinal plants; Methanol - chemistry; Microbial Sensitivity Tests; Microspectrophotometry; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - growth & development; nuclear magnetic resonance spectroscopy; Phytotherapy; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Roots; Plants, Medicinal; psoralens; roots; Solvents - chemistry; tuberculosis; North America; Canada; DMSO; (3R8S)-falcarindiol; [α]D; TLC; bs; SD; C-17 diynes; 2D; HRESIMS; IC50; nBuOH; Furanocoumarins; HPLC; CH2Cl2; EtOAc; c; d; MIC; MS; LC–MS; IR; m; ACS; q; NMR; 1D; s; t; Heracleum maximum; Mycobacterium tuberculosis; MeOH; NaCl; MRA; Antimycobacterial activity

Heracleum maximum is amongst the most commonly used plants by the indigenous peoples of North America. The First Nations of the eastern Canada use infusions of Heracleum maximum roots for the treatment of respiratory ailments including tuberculosis. Previous investigations of extracts derived from t...