Analytical and Non-Analytical Variation May Lead to Inappropriate Antimicrobial Dosing in Neonates: An In Silico Study

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 69; no. 6; pp. 637 - 648
• Main Authors: Nguyen, Thi A, Kirubakaran, Ranita, Schultz, Hayley B, Wong, Sherilyn, Reuter, Stephanie E, McMullan, Brendan, Bolisetty, Srinivas, Campbell, Craig, Horvath, Andrea R, Stocker, Sophie L
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.06.2023
• Subjects: Aminoglycosides; Anti-Bacterial Agents - therapeutic use; Drug Monitoring - methods; Humans; Infant, Newborn; Retrospective Studies; Vancomycin - pharmacokinetics; Vancomycin - therapeutic use

Abstract Background Therapeutic drug monitoring (TDM) of aminoglycosides and vancomycin is used to prevent oto- and nephrotoxicity in neonates. Analytical and nonanalytical factors potentially influence dosing recommendations. This study aimed to determine the impact of analytical variation (impreci...