Increase in endogenous estradiol in the progeny of obese rats is associated with precocious puberty and altered follicular development in adulthood

• Published in: Endocrine Vol. 53; no. 1; pp. 258 - 270
• Main Authors: Ambrosetti, Valery, Guerra, Marcelo, Ramírez, Luisa A., Reyes, Aldo, Álvarez, Daniela, Olguín, Sofía, González-Mañan, Daniel, Fernandois, Daniela, Sotomayor-Zárate, Ramón, Cruz, Gonzalo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2016
• Subjects: Androstenedione - blood; Animals; Body Weight - physiology; Cytochrome P-450 CYP3A - metabolism; Diabetes; Diet, High-Fat; Endocrinology; Estradiol - blood; Estriol - blood; Female; Follicle Stimulating Hormone - blood; Humanities and Social Sciences; Insulin - blood; Internal Medicine; Liver - metabolism; Luteinizing Hormone - blood; Maternal Nutritional Physiological Phenomena; Medicine; Medicine & Public Health; multidisciplinary; Obesity - blood; Obesity - metabolism; Original Article; Pregnancy; Prenatal Exposure Delayed Effects - blood; Prenatal Exposure Delayed Effects - metabolism; Rats; Rats, Sprague-Dawley; Science; Sexual Maturation - physiology; Ovary; Maternal obesity; CYP3A2; Estradiol

Maternal obesity during pregnancy has been related with several pathological states in offspring. However, the impact of maternal obesity on reproductive system on the progeny is beginning to be elucidated. In this work, we characterize the effect of maternal obesity on puberty onset and follicular...