Exploration of Multiple Signaling Pathways Through Which Sodium Tanshinone IIA Sulfonate Attenuates Pathologic Remodeling Experimental Infarction

• Published in: Frontiers in pharmacology Vol. 10; p. 779
• Main Authors: Mao, Shuai, Vincent, Matthew, Chen, Maosheng, Zhang, Minzhou, Hinek, Aleksander
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.07.2019
• Subjects: AMP kinase pathway; apoptosis; autophagy; cardiac remodeling; Pharmacology; sodium tanshinone IIA sulfonate; AMP kinase pathway; apoptosis; autophagy; sodium tanshinone IIA sulfonate; cardiac remodeling

The level of maladaptive myocardial remodeling consistently contributes to the poor prognosis of patients following a myocardial infarction (MI). In this study, we investigated whether and how sodium tanshinone IIA sulfonate (STS) would attenuate the post-infarct cardiac remodeling in mice model of...