Mitochondria, energy, and metabolism in neuronal health and disease

• Published in: FEBS letters Vol. 596; no. 9; pp. 1095 - 1110
• Main Authors: Trigo, Diogo, Avelar, Catarina, Fernandes, Miguel, Sá, Juliana, Cruz e Silva, Odete
• Format: Journal Article
• Language: English
• Published: England 01.05.2022
• Subjects: ageing; Alzheimer; axon; brain; cognitive disorders; energy; homeostasis; Huntington; metabolism; mitochondria; mitophagy; neurodegeneration; neurodegenerative diseases; neuron; neurons; neuropathology; oxidative stress; Parkinson; ROS; stress response; therapeutics; ageing; mitophagy; mitochondria; ROS; neurodegeneration; neuron; Huntington; axon; Alzheimer; Parkinson

Mitochondria are associated with various cellular activities critical to homeostasis, particularly in the nervous system. The plastic architecture of the mitochondrial network and its dynamic structure play crucial roles in ensuring that varying energetic demands are rapidly met to maintain neuronal...