An Optimized Competitive-Aging Method Reveals Gene-Drug Interactions Underlying the Chronological Lifespan of Saccharomyces cerevisiae

• Published in: Frontiers in genetics Vol. 11; p. 468
• Main Authors: Avelar-Rivas, J Abraham, Munguía-Figueroa, Michelle, Juárez-Reyes, Alejandro, Garay, Erika, Campos, Sergio E, Shoresh, Noam, DeLuna, Alexander
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.05.2020
• Subjects: gene-drug interactions; genetic analysis; Genetics; high-throughput screening; post-mitotic aging; Saccharomyces cerevisiae; gene-drug interactions; genetic analysis; post-mitotic aging; Saccharomyces cerevisiae; high-throughput screening

The chronological lifespan of budding yeast is a model of aging and age-related diseases. This paradigm has recently allowed genome-wide screening of genetic factors underlying post-mitotic viability in a simple unicellular system, which underscores its potential to provide a comprehensive view of t...