Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

• Published in: Advanced science Vol. 10; no. 31; pp. e2303167 - n/a
• Main Authors: Wang, Shuangqing, Liu, Yanhong, Sun, Qianwen, Zeng, Bowen, Liu, Chao, Gong, Liming, Wu, Hao, Chen, Liqing, Jin, Mingji, Guo, Jianpeng, Gao, Zhonggao, Huang, Wei
• Format: Journal Article
• Language: English
• Published: Weinheim John Wiley & Sons, Inc 01.11.2023; John Wiley and Sons Inc; Wiley
• Subjects: Antioxidants; Apoptosis; Biocompatibility; Biomedical materials; Chemical bonds; Cytokines; Hydrogels; Hydrogen bonds; Inflammation; injectable hydrogel; Kinases; Mechanical properties; Nanoparticles; Particle size; Polymers; reactive oxygen species; rheumatoid arthritis; Selenium; selenium nanoparticles; Tumor necrosis factor-TNF; wound healing

Modulating the inflammatory microenvironment can inhibit the process of inflammatory diseases (IDs). A tri‐cross‐linked inflammatory microenvironment‐responsive hydrogel with ideal mechanical properties achieves triggerable and sustained drug delivery and regulates the inflammatory microenvironment....