The dual nature of mismatch repair as antimutator and mutator: for better or for worse

• Published in: Frontiers in genetics Vol. 5; p. 287
• Main Authors: Bak, Sara Thornby, Sakellariou, Despoina, Pena-Diaz, Javier
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2014
• Subjects: antibody diversification; Class switch recombination; Genetics; Neurodegenerative Diseases; non-canonical mismatch repair; somatic hypermutation; Trinucleotide Repeats; neurodegenerative diseases; non-canonical mismatch repair; somatic hypermutation; antibody diversification; trinucleotide repeats; class switch recombination; chromatin modifiers

DNA is constantly under attack by a number of both exogenous and endogenous agents that challenge its integrity. Among the mechanisms that have evolved to counteract this deleterious action, mismatch repair (MMR) has specialized in removing DNA biosynthetic errors that occur when replicating the gen...