A Novel Combination of Serum Markers in a Multivariate Model to Help Triage Patients Into "Low-" and "High-Risk" Categories for Prostate Cancer

• Published in: Frontiers in oncology Vol. 12; p. 837127
• Main Authors: McNally, Christopher J, Watt, Joanne, Kurth, Mary Jo, Lamont, John V, Moore, Tara, Fitzgerald, Peter, Pandha, Hardev, McKenna, Declan J, Ruddock, Mark W
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.05.2022
• Subjects: algorithm; EGF; fPSA; IL-8; marker; MCP-1; Oncology; MCP-1; prostate cancer; EGF; marker; fPSA; IL-8; algorithm; tPSA

Almost 50,000 men in the United Kingdom (UK) are diagnosed each year with prostate cancer (PCa). Secondary referrals for investigations rely on serum prostate-specific antigen (PSA) levels and digital rectal examination. However, both tests lack sensitivity and specificity, resulting in unnecessary...