Denosumab May Increase the Risk of Local Recurrence in Patients with Giant-Cell Tumor of Bone Treated with Curettage

• Published in: Journal of bone and joint surgery. American volume Vol. 100; no. 6; p. 496
• Main Authors: Errani, Costantino, Tsukamoto, Shinji, Leone, Giulio, Righi, Alberto, Akahane, Manabu, Tanaka, Yasuhito, Donati, Davide Maria
• Format: Journal Article
• Language: English
• Published: United States 21.03.2018
• Subjects: Adult; Bone Density Conservation Agents - therapeutic use; Bone Neoplasms - drug therapy; Bone Neoplasms - surgery; Curettage; Denosumab - therapeutic use; Disease-Free Survival; Female; Giant Cell Tumor of Bone - drug therapy; Giant Cell Tumor of Bone - surgery; Humans; Male; Neoplasm Recurrence, Local - epidemiology; Retrospective Studies

Recent clinical studies have suggested that denosumab is associated with tumor response and reduced surgical morbidity in patients with giant-cell tumor of bone (GCTB). We therefore evaluated the recurrence-free survival rate of patients who had GCTB in an extremity and were treated with surgery and...