Cell-free fetal DNA concentration in plasma of patients with abnormal uterine artery Doppler waveform and intrauterine growth restriction-a pilot study

Objective To evaluate if an increased amount of fetal DNA concentration can be found in women screened positive for intrauterine growth restriction because of abnormal uterine artery Doppler waveforms. Methods We enrolled eight pregnant women (each bearing a male fetus), with the evidence of abnorma...

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Published inPrenatal diagnosis Vol. 23; no. 5; pp. 367 - 371
Main Authors Caramelli, Elisabetta, Rizzo, Nicola, Concu, Manuela, Simonazzi, Giuliana, Carinci, Paolo, Bondavalli, Corrado, Bovicelli, Luciano, Farina, Antonio
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.05.2003
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Abstract Objective To evaluate if an increased amount of fetal DNA concentration can be found in women screened positive for intrauterine growth restriction because of abnormal uterine artery Doppler waveforms. Methods We enrolled eight pregnant women (each bearing a male fetus), with the evidence of abnormal uterine artery Doppler waveforms, and 16 control patients for a case‐control study matched for gestational age (1 : 2). Uterine artery Doppler was carried out at 20 to 35 weeks' gestation (median 29). The mean uterine artery resistance index (RI) was subsequently calculated, and a value >0.6 was considered positive for the clinical features of pre‐eclampsia. The SRY locus was used to determine the amount of male fetal DNA in the maternal plasma at the time of Doppler analysis. Results Two controls (normal Doppler) were excluded from the final analysis because they had a pre‐term delivery. One case (abnormal Doppler) had evidence of intrauterine growth restriction at the time of enrolment. In four out of eight cases (abnormal Doppler), intrauterine growth restriction was subsequently observed. Multiples of median (MoM) conversion of the fetal DNA values showed an increase of 1.81 times in the cases when compared to the controls. An increase of 2.16 times was instead observed for the cases with a growth‐restricted fetus (5 cases out of 8) in comparison with the controls (14 cases). Conclusions In subjects positive to uterine artery Doppler velocimetry analysis (Doppler analysis for pre‐eclampsia screening), the fetal DNA concentration is higher than expected, in the absence of any other clinical feature. Since the increase in fetal DNA seems to be related to the presence or to the future development of intrauterine growth restriction, this paper suggests a possible integration between ultrasound and molecular markers for predicting the disease in some cases. Copyright © 2003 John Wiley & Sons, Ltd.
AbstractList OBJECTIVETo evaluate if an increased amount of fetal DNA concentration can be found in women screened positive for intrauterine growth restriction because of abnormal uterine artery Doppler waveforms.METHODSWe enrolled eight pregnant women (each bearing a male fetus), with the evidence of abnormal uterine artery Doppler waveforms, and 16 control patients for a case-control study matched for gestational age (1 : 2). Uterine artery Doppler was carried out at 20 to 35 weeks' gestation (median 29). The mean uterine artery resistance index (RI) was subsequently calculated, and a value >0.6 was considered positive for the clinical features of pre-eclampsia. The SRY locus was used to determine the amount of male fetal DNA in the maternal plasma at the time of Doppler analysis.RESULTSTwo controls (normal Doppler) were excluded from the final analysis because they had a pre-term delivery. One case (abnormal Doppler) had evidence of intrauterine growth restriction at the time of enrolment. In four out of eight cases (abnormal Doppler), intrauterine growth restriction was subsequently observed. Multiples of median (MoM) conversion of the fetal DNA values showed an increase of 1.81 times in the cases when compared to the controls. An increase of 2.16 times was instead observed for the cases with a growth-restricted fetus (5 cases out of 8) in comparison with the controls (14 cases).CONCLUSIONSIn subjects positive to uterine artery Doppler velocimetry analysis (Doppler analysis for pre-eclampsia screening), the fetal DNA concentration is higher than expected, in the absence of any other clinical feature. Since the increase in fetal DNA seems to be related to the presence or to the future development of intrauterine growth restriction, this paper suggests a possible integration between ultrasound and molecular markers for predicting the disease in some cases.
To evaluate if an increased amount of fetal DNA concentration can be found in women screened positive for intrauterine growth restriction because of abnormal uterine artery Doppler waveforms. We enrolled eight pregnant women (each bearing a male fetus), with the evidence of abnormal uterine artery Doppler waveforms, and 16 control patients for a case-control study matched for gestational age (1 : 2). Uterine artery Doppler was carried out at 20 to 35 weeks' gestation (median 29). The mean uterine artery resistance index (RI) was subsequently calculated, and a value >0.6 was considered positive for the clinical features of pre-eclampsia. The SRY locus was used to determine the amount of male fetal DNA in the maternal plasma at the time of Doppler analysis. Two controls (normal Doppler) were excluded from the final analysis because they had a pre-term delivery. One case (abnormal Doppler) had evidence of intrauterine growth restriction at the time of enrolment. In four out of eight cases (abnormal Doppler), intrauterine growth restriction was subsequently observed. Multiples of median (MoM) conversion of the fetal DNA values showed an increase of 1.81 times in the cases when compared to the controls. An increase of 2.16 times was instead observed for the cases with a growth-restricted fetus (5 cases out of 8) in comparison with the controls (14 cases). In subjects positive to uterine artery Doppler velocimetry analysis (Doppler analysis for pre-eclampsia screening), the fetal DNA concentration is higher than expected, in the absence of any other clinical feature. Since the increase in fetal DNA seems to be related to the presence or to the future development of intrauterine growth restriction, this paper suggests a possible integration between ultrasound and molecular markers for predicting the disease in some cases.
Objective To evaluate if an increased amount of fetal DNA concentration can be found in women screened positive for intrauterine growth restriction because of abnormal uterine artery Doppler waveforms. Methods We enrolled eight pregnant women (each bearing a male fetus), with the evidence of abnormal uterine artery Doppler waveforms, and 16 control patients for a case‐control study matched for gestational age (1 : 2). Uterine artery Doppler was carried out at 20 to 35 weeks' gestation (median 29). The mean uterine artery resistance index (RI) was subsequently calculated, and a value >0.6 was considered positive for the clinical features of pre‐eclampsia. The SRY locus was used to determine the amount of male fetal DNA in the maternal plasma at the time of Doppler analysis. Results Two controls (normal Doppler) were excluded from the final analysis because they had a pre‐term delivery. One case (abnormal Doppler) had evidence of intrauterine growth restriction at the time of enrolment. In four out of eight cases (abnormal Doppler), intrauterine growth restriction was subsequently observed. Multiples of median (MoM) conversion of the fetal DNA values showed an increase of 1.81 times in the cases when compared to the controls. An increase of 2.16 times was instead observed for the cases with a growth‐restricted fetus (5 cases out of 8) in comparison with the controls (14 cases). Conclusions In subjects positive to uterine artery Doppler velocimetry analysis (Doppler analysis for pre‐eclampsia screening), the fetal DNA concentration is higher than expected, in the absence of any other clinical feature. Since the increase in fetal DNA seems to be related to the presence or to the future development of intrauterine growth restriction, this paper suggests a possible integration between ultrasound and molecular markers for predicting the disease in some cases. Copyright © 2003 John Wiley & Sons, Ltd.
Author Rizzo, Nicola
Simonazzi, Giuliana
Concu, Manuela
Carinci, Paolo
Farina, Antonio
Bovicelli, Luciano
Caramelli, Elisabetta
Bondavalli, Corrado
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  email: farina@alma.unibo.it
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Issue 5
Keywords Sonography
Doppler ultrasound study
Waveform
Human
Intrauterine growth retardation
Pregnancy disorders
Growth
cell-free fetal DNA
Uterine artery
Blood plasma
Arterial disease
Prenatal
Fetal diseases
Mother
DNA
Fetus
Diagnosis
uterine artery Doppler screening
Language English
License CC BY 4.0
Copyright 2003 John Wiley & Sons, Ltd.
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SSID ssj0028297
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Snippet Objective To evaluate if an increased amount of fetal DNA concentration can be found in women screened positive for intrauterine growth restriction because of...
To evaluate if an increased amount of fetal DNA concentration can be found in women screened positive for intrauterine growth restriction because of abnormal...
OBJECTIVETo evaluate if an increased amount of fetal DNA concentration can be found in women screened positive for intrauterine growth restriction because of...
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crossref
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pascalfrancis
wiley
istex
SourceType Aggregation Database
Index Database
Publisher
StartPage 367
SubjectTerms Adult
Arteries - diagnostic imaging
Biological and medical sciences
Case-Control Studies
cell-free fetal DNA
Chromosomes, Human, Y
Diseases of mother, fetus and pregnancy
DNA - blood
Female
Fetal Blood
Fetal Growth Retardation - blood
Fetal Growth Retardation - diagnostic imaging
Fetus - metabolism
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
intrauterine growth retardation
Male
Management. Prenatal diagnosis
Medical sciences
Pilot Projects
Pre-Eclampsia - blood
Pre-Eclampsia - diagnostic imaging
Pregnancy - blood
Pregnancy. Fetus. Placenta
Reverse Transcriptase Polymerase Chain Reaction
Sex Determination Analysis
Ultrasonography, Doppler
Ultrasonography, Prenatal
uterine artery Doppler screening
Uterus - blood supply
Uterus - diagnostic imaging
Title Cell-free fetal DNA concentration in plasma of patients with abnormal uterine artery Doppler waveform and intrauterine growth restriction-a pilot study
URI https://api.istex.fr/ark:/67375/WNG-54GGC2QW-6/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpd.596
https://www.ncbi.nlm.nih.gov/pubmed/12749031
https://search.proquest.com/docview/73289568
Volume 23
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