Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1α gene mutations: evidence for pharmacogenetics in diabetes

• Published in: Diabetic medicine Vol. 17; no. 7; pp. 543 - 545
• Main Authors: Pearson, E. R., Liddell, W. G., Shepherd, M., Corrall, R. J., Hattersley, A. T.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.07.2000; Blackwell
• Subjects: Biological and medical sciences; Hormones. Endocrine system; Medical sciences; Pharmacology. Drug treatments; Endocrinopathy; Human; Maturity onset diabetes young; Transcription factor HNF1; Hypoglycemic agent; Pharmacogenetics; Treatment efficiency; Sulfonylureas; Adult; Mutation; Transcription factor; Genetic determinism

SUMMARY Introduction  Maturity‐onset diabetes of the young (MODY) is characterized by autosomal dominantly inherited, early‐onset, non‐insulin‐dependent diabetes. Mutations in the hepatocyte nuclear factor (HNF)‐1α gene are the commonest cause of MODY. Individual patients with HNF‐1α mutations have...