Molecular Dynamics Simulation of the Influenza A(H3N2) Hemagglutinin Trimer Reveals the Structural Basis for Adaptive Evolution of the Recent Epidemic Clade 3C.2a

• Published in: Frontiers in microbiology Vol. 8; p. 584
• Main Authors: Yokoyama, Masaru, Fujisaki, Seiichiro, Shirakura, Masayuki, Watanabe, Shinji, Odagiri, Takato, Ito, Kimito, Sato, Hironori
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.04.2017
• Subjects: Microbiology; MD simulation; influenza A(H3N2); N-linked glycans; structural change; mutations; HA protein

Influenza A(H3N2) has been a major cause of seasonal influenza in humans since 1968, and has evolved by antigenic drift under the constantly changing human herd immunity. Increasing evidence suggests that the antigenic change occasionally occurred concomitant with the alterations of the N-glycosylat...