Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells

• Published in: Frontiers in physiology Vol. 8; p. 634
• Main Authors: Chang, Hsueh-Wei, Li, Ruei-Nian, Wang, Hui-Ru, Liu, Jing-Ru, Tang, Jen-Yang, Huang, Hurng-Wern, Chan, Yu-Hsuan, Yen, Ching-Yu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.09.2017
• Subjects: apoptosis; N-acetylcysteine; oral cancer; oxidative stress; Physiology; selective killing; withaferin A; selective killing; apoptosis; withaferin A; oral cancer; oxidative stress; N-acetylcysteine

Withaferin A (WFA) is one of the most active steroidal lactones with reactive oxygen species (ROS) modulating effects against several types of cancer. ROS regulation involves selective killing. However, the anticancer and selective killing effects of WFA against oral cancer cells remain unclear. We...