Growth abnormalities of cultured human skin fibroblasts derived from individuals with hereditary adenomatosis of the colon and rectum

• Published in: Journal of cellular physiology Vol. 89; no. 1; p. 29
• Main Authors: Pfeffer, L, Lipkin, M, Stutman, O, Kopelovich, L
• Format: Journal Article
• Language: English
• Published: United States 01.09.1976
• Subjects: Animals; Blood; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Culture Media; Humans; Intestinal Polyps - genetics; Intestinal Polyps - pathology; Mice; Mice, Inbred BALB C; Neoplasms, Experimental - etiology; Rats; Rectal Neoplasms - genetics; Rectal Neoplasms - pathology
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040890104

A heritable propensity to develop malignant lesions is found in individuals with familial adenomatosis of the colon an rectum (ACR) and the Gardner's syndrome variant, an autosomal dominant trait. In the present study, the growth characteristics of cultured skin fibroblasts (SF) derived from no...