Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34 + Cells

• Published in: Frontiers in immunology Vol. 9; p. 2734
• Main Authors: Theobald, Sebastian J, Khailaie, Sahamoddin, Meyer-Hermann, Michael, Volk, Valery, Olbrich, Henning, Danisch, Simon, Gerasch, Laura, Schneider, Andreas, Sinzger, Christian, Schaudien, Dirk, Lienenklaus, Stefan, Riese, Peggy, Guzman, Carlos A, Figueiredo, Constanca, von Kaisenberg, Constantin, Spineli, Loukia M, Glaesener, Stephanie, Meyer-Bahlburg, Almut, Ganser, Arnold, Schmitt, Michael, Mach, Michael, Messerle, Martin, Stripecke, Renata
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 22.11.2018
• Subjects: B cell class switch; HCMV; humanized mice; Immunology; optical imaging analyses; reactivation; T cell maturation; HCMV; T cell maturation; humanized mice; linear discriminant analyses; reactivation; principal component analyses; optical imaging analyses; B cell class switch

Human cytomegalovirus (HCMV) latency is typically harmless but reactivation can be largely detrimental to immune compromised hosts. We modeled latency and reactivation using a traceable HCMV laboratory strain expressing the luciferase reporter gene (HCMV/GLuc) in order to interrogate the viral modul...