The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 242; no. 10; pp. 1034 - 1043
• Main Authors: Gao, Chang, Sun, Rui, Xie, Ya-Rong, Jiang, An-Li, Lin, Mei, Li, Min, Chen, Zheng-Wang, Zhang, Ping, Jin, Honglin, Feng, Jue-Ping
• Format: Journal Article
• Language: English
• Published: England SAGE Publications 01.05.2017
• Subjects: Animals; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Cell Line, Tumor; Cell Survival - drug effects; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; Disease Models, Animal; Epithelial Cells - drug effects; Epithelial Cells - physiology; Heterografts - pathology; Humans; Mice; Original Research; Soybean Proteins - pharmacology; Treatment Outcome; apoptosis; soybean peptide; antiproliferation; cell cycle; colon cancer; Vglycin

Vglycin, a novel natural polypeptide isolated from pea seeds, possesses antidiabetic properties. Our previous studies have shown that Vglycin can induce the differentiation of human colon adenocarcinoma cells. We aimed to determine the anticancer activity of Vglycin against colon cancer cells and to...