Praziquantel in the cerebrospinal fluid in neurocysticercosis

• Published in: Arquivos de neuro-psiquiatria Vol. 43; no. 3; pp. 243 - 259
• Main Authors: Spina-França, A, Machado, L R, Nóbrega, J P, Livramento, J A, Diekmann, H W, Groll, E, de Rezende, G L
• Format: Journal Article
• Language: English
• Published: Brazil Academia Brasileira de Neurologia - ABNEURO 01.09.1985; Academia Brasileira de Neurologia (ABNEURO)
• Subjects: Adolescent; Adult; Blood-Brain Barrier; Central Nervous System Diseases - cerebrospinal fluid; Cysticercosis - cerebrospinal fluid; Female; Humans; Kinetics; Male; Middle Aged; NEUROSCIENCES; Praziquantel - blood; Praziquantel - cerebrospinal fluid; Praziquantel - metabolism; PSYCHIATRY

In 10 patients with neurocysticercosis (NC), an assessment was made of the praziquantel (PZQ) concentration in the cerebrospinal fluid (CSF), in non-deproteinized serum and in protein-free serum: before administration of the drug and the 1st., 7th. and 21st. days of oral administration (50mg/kg/day...