Exploring mitochondrial DNA copy number in circulating cell‐free DNA and extracellular vesicles across cardiovascular health status: A prospective case–control pilot study

• Published in: The FASEB journal Vol. 38; no. 10; pp. e23672 - n/a
• Main Authors: Rucci, Chiara, Simone, Gaia, Salathia, Saniya, Casadidio, Cristina, Censi, Roberta, Bordoni, Laura
• Format: Journal Article
• Language: English
• Published: United States 31.05.2024
• Subjects: Aged; Cardiovascular Diseases - blood; Cardiovascular Diseases - genetics; Case-Control Studies; Cell-Free Nucleic Acids - blood; Cell-Free Nucleic Acids - genetics; cell‐free DNA; CVD; DNA Copy Number Variations; DNA, Mitochondrial - blood; DNA, Mitochondrial - genetics; extracellular vesicles; Extracellular Vesicles - genetics; Extracellular Vesicles - metabolism; Female; heart attack; Humans; Male; Middle Aged; mitochondrial DNA; Pilot Projects; Prospective Studies; CVD; extracellular vesicles; heart attack; mitochondrial DNA; cell‐free DNA

Cardiovascular disease (CVD) is a leading global cause of mortality, difficult to predict in advance. Evidence indicates that the copy number of mitochondrial DNA (mtDNAcn) in blood is altered in individuals with CVD. MtDNA released into circulation may act as a mediator of inflammation, a recognize...