Integrative Transcriptomic and Small RNA Sequencing Reveals Immune-Related miRNA–mRNA Regulation Network for Soybean Meal-Induced Enteritis in Hybrid Grouper, Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus

• Published in: Frontiers in immunology Vol. 11; p. 1502
• Main Authors: He, Yuanfa, Ye, Guanlin, Chi, Shuyan, Tan, Beiping, Dong, Xiaohui, Yang, Qihui, Liu, Hongyu, Zhang, Shuang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.08.2020
• Subjects: Animals; Cytotoxicity, Immunologic; Enteritis - immunology; Fish Diseases - immunology; Fishes - physiology; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; hybrid grouper; immune response; Immunity - genetics; Immunoglobulin A - biosynthesis; Immunology; inflammation; Integrative Medicine; intestinal health; MicroRNAs - genetics; MicroRNAs - immunology; Phagocytosis; RNA, Messenger - genetics; RNA-seq; Sequence Analysis, RNA; intestinal health; RNA-seq; immune response; inflammation; hybrid grouper

A 10-week feeding experiment was conducted to reveal the immune mechanism for soybean meal-induced enteritis (SBMIE) in hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂. Four isonitrogenous and isolipidic diets were formulated by replacing 0, 10, 30, and 50% fish meal protein...