Coordinate regulation of protein synthesis and messenger RNA content during growth arrest of suspension Chinese hamster ovary cells

• Published in: Journal of cellular physiology Vol. 90; no. 3; p. 485
• Main Authors: Levis, R, McReynolds, L, Penman, S
• Format: Journal Article
• Language: English
• Published: United States 01.03.1977
• Subjects: Animals; Blood; Cell Division; Cell Line; Cricetinae; Culture Media; Female; Poly A - analysis; Polyribosomes - analysis; Protein Biosynthesis; RNA, Messenger - analysis; RNA, Messenger - metabolism; RNA, Ribosomal - analysis

We have found Chinese Hamster Ovary cells, cultured in suspension, are subject to growth control by serum. When suspended in medium containing 0.5% serum the cells becomes reversibly arrested in the beginning of the G1 phase of the cell cycle and can be maintained in this viable, nonproliferating st...