Antagonistic roles of Ras-MAPK and Akt signaling in integrin-K + channel complex-mediated cellular apoptosis

• Published in: The FASEB journal Vol. 36; no. 5; p. e22292
• Main Authors: Forzisi, Elena, Yu, Wei, Rajwade, Parth, Sesti, Federico
• Format: Journal Article
• Language: English
• Published: United States 01.05.2022
• Subjects: Apoptosis - physiology; Cell Survival - physiology; Integrins - physiology; Proto-Oncogene Proteins c-akt; Signal Transduction - physiology; apoptosis; potassium channel; integrin; neuroscience; oxidative stress

Complexes formed with α5-integrins and the voltage-gated potassium (K ) channel KCNB1 (Kv2.1), known as IKCs, transduce the electrical activity at the plasma membrane into biochemical events that impinge on cytoskeletal remodeling, cell differentiation, and migration. However, when cells are subject...