Epinephrine Infusion in the Evaluation of Unexplained Cardiac Arrest and Familial Sudden Death: From the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry

• Published in: Circulation. Arrhythmia and electrophysiology Vol. 5; no. 5; pp. 933 - 940
• Main Authors: Krahn, Andrew D., Healey, Jeffrey S., Chauhan, Vijay S., Birnie, David H., Champagne, Jean, Sanatani, Shubhayan, Ahmad, Kamran, Ballantyne, Emily, Gerull, Brenda, Yee, Raymond, Skanes, Allan C., Gula, Lorne J., Leong-Sit, Peter, Klein, George J., Gollob, Michael H., Simpson, Christopher S., Talajic, Mario, Gardner, Martin
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.10.2012; Lippincott Williams & Wilkins
• Subjects: Adolescent; Adult; Aged; Analysis of Variance; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Canada - epidemiology; Cardiac dysrhythmias; Cardiology. Vascular system; Cardiovascular system; Chi-Square Distribution; Death, Sudden, Cardiac - epidemiology; Electrocardiography; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Epinephrine - administration & dosage; Exercise Test; Female; General aspects. Genetic counseling; Heart; Heart Rate - physiology; Humans; Infusions, Intravenous; Intensive care medicine; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Long QT Syndrome - diagnosis; Long QT Syndrome - genetics; Long QT Syndrome - physiopathology; Male; Medical genetics; Medical sciences; Middle Aged; Registries; Stroke Volume; Survivors; Tachycardia, Ventricular - diagnosis; Tachycardia, Ventricular - genetics; Tachycardia, Ventricular - physiopathology; Vasoconstrictor Agents - administration & dosage; Canada; Epinephrine; Evaluation; Cardiocirculatory arrest; Arrhythmia; Family study; Survivor; Sudden death; Prolonged QT interval; Cardiovascular disease; Ventricular tachycardia; Conduction disorder; long-QT syndrome; Infusion; Genetic counseling; catecholaminergic polymorphic ventricular tachycardia; Heart block; Heart disease; genetic testing; Diagnosis; Hemodynamics; Ejection fraction

BACKGROUND—Epinephrine infusion may unmask latent genetic conditions associated with cardiac arrest, including long-QT syndrome and catecholaminergic polymorphic ventricular tachycardia (VT). METHODS AND RESULTS—Patients with unexplained cardiac arrest (normal left ventricular function and QT interv...