A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo

• Published in: Oncogene Vol. 32; no. 37; pp. 4406 - 4416
• Main Authors: Eberlein, C, Kendrew, J, McDaid, K, Alfred, A, Kang, J S, Jacobs, V N, Ross, S J, Rooney, C, Smith, N R, Rinkenberger, J, Cao, A, Churchman, A, Marshall, J F, Weir, H M, Bedian, V, Blakey, D C, Foltz, I N, Barry, S T
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.09.2013; Nature Publishing Group
• Subjects: 631/67/1059/602; 631/67/1857; 631/67/322; Actin; Animals; Antibodies, Monoclonal, Humanized - immunology; Antibodies, Monoclonal, Humanized - metabolism; Antibodies, Monoclonal, Humanized - pharmacology; Antigens, Neoplasm - immunology; Antigens, Neoplasm - metabolism; Apoptosis; Biomarkers - metabolism; Cancer; Care and treatment; Cell activation; Cell Biology; Cell culture; Cell Line; Cell Movement - drug effects; Cell Proliferation - drug effects; Coculture Techniques; Female; Fibroblasts; Fibronectin; Human Genetics; Humans; Integrins; Integrins - antagonists & inhibitors; Integrins - immunology; Integrins - metabolism; Internal Medicine; Latency; Lung Neoplasms - drug therapy; Lung Neoplasms - metabolism; Lung Neoplasms - secondary; Macaca fascicularis; Matrix metalloproteinase; Matrix Metalloproteinase 9 - biosynthesis; Medicine; Medicine & Public Health; Metalloproteinase; Metastases; Metastasis; Mice; Monoclonal antibodies; Neoplasms - metabolism; Neoplasms - pathology; Neoplastic processes; Observations; Oncology; original-article; Properties; Protein Binding; Smooth muscle; Testing; Transforming Growth Factor beta - metabolism; Transforming growth factor-b; Tumors; Xenograft Model Antitumor Assays; United Kingdom; United States > US; Detroit Michigan; beta-6; TGF-β; beta-8; αvβ8; integrin; αvβ6

αvβ6 integrin expression is upregulated on a wide range of epithelial tumours, and is thought to play a role in modulating tumour growth. Here we describe a human therapeutic antibody 264RAD, which binds and inhibits αvβ6 integrin function. 264RAD cross-reacts with human, mouse and cynomolgus monkey...