Vaginal Epithelial Cells Discriminate Between Yeast and Hyphae of Candida albicans in Women Who Are Colonized or Have Vaginal Candidiasis

• Published in: The Journal of infectious diseases Vol. 220; no. 10; pp. 1645 - 1654
• Main Authors: Roselletti, Elena, Perito, Stefano, Sabbatini, Samuele, Monari, Claudia, Vecchiarelli, Anna
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 08.10.2019
• Subjects: Adult; Asymptomatic; c-Fos protein; Candida albicans; Candida albicans - growth & development; Candidiasis; Candidiasis, Vulvovaginal - pathology; Carrier State - immunology; Cell Survival; Commensalism; Enzyme-linked immunosorbent assay; EphA2 protein; Epithelial cells; Epithelial Cells - immunology; Epithelial Cells - microbiology; Epithelial Cells - physiology; Erythropoietin; Female; FUNGI; Hepatoma; Humans; Hyphae; Hyphae - growth & development; Immunologic Factors - analysis; L-Lactate dehydrogenase; Lactic acid; Liver cancer; Middle Aged; NF-κB protein; Pattern recognition receptors; Pseudohyphae; TLR2 protein; TLR4 protein; Toll-like receptors; Transcription activation; Transcription factors; Vagina; Vagina - microbiology; Womens health; Young Adult; inflammation; pseudohyphae; hyphae; p-p38; c-Fos; human vaginal candidiasis; epithelial cells; yeast; C. albicans

Abstract Background Vaginal candidiasis is common disease affecting women; however, how Candida albicans shift from commensalism towards a pathogenic status remains poorly understood. The present study investigated the vaginal epithelial cell (EC) response dynamics under various conditions. Methods...