Time course of changes in cocaine self-administration behavior in rats during immunization with the cocaine vaccine IPC-1010

• Published in: Psychopharmacologia Vol. 153; no. 3; pp. 334 - 340
• Main Authors: Kantak, Kathleen M., Collins, Stephanie L., Bond, Julian, Fox, Barbara S.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.01.2001; Springer Nature B.V
• Subjects: Animals; Antibodies; Antibodies - blood; Behavior, Addictive - blood; Behavior, Addictive - prevention & control; Behavior, Addictive - psychology; Biological and medical sciences; Cocaine; Cocaine - immunology; Cocaine - pharmacology; Cocaine-Related Disorders - blood; Cocaine-Related Disorders - drug therapy; Cocaine-Related Disorders - psychology; Dopamine Uptake Inhibitors - immunology; Dopamine Uptake Inhibitors - pharmacology; Dose-Response Relationship, Drug; Drug abuse; Drug addiction; Drug addictions; Drug self-administration; Eating - drug effects; Eating - psychology; Immunization; IPC-1010; Male; Medical sciences; Rats; Rats, Wistar; Self Administration - psychology; Toxicology; Vaccines; Vaccines - pharmacology; Vaccines - therapeutic use; Intraperitoneal administration; Intravenous administration; Rat; Psychotropic; Toxicity; Self administration; Searching behavior; Learning; Ester; Acquisition process; Reinforcement; Drug of abuse; Consumption; Drug addiction; Immunization; CNS stimulant; Antibody; Illicit drug; Rodentia; Instrumental conditioning; Vaccine; Long term; Biological activity; Vertebrata; Chemotherapy; Mammalia; Treatment; Food intake; Animal; Cocaine

Following a 6-week immunization period consisting of three biweekly injections of the cocaine vaccine IPC-1010, the reacquisition of cocaine self-administration behavior in rats was previously shown to be reduced in a manner that was dependant on serum antibody level. The present studies were conduc...