Isoflavones Promote Mitochondrial Biogenesis

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 325; no. 2; pp. 536 - 543
• Main Authors: Rasbach, Kyle A., Schnellmann, Rick G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2008; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Animals; Cells, Cultured; Female; Isoflavones - pharmacology; Kidney Tubules, Proximal - cytology; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial Proton-Translocating ATPases - metabolism; Oxygen Consumption; Rabbits; RNA-Binding Proteins - metabolism; Sirtuins - metabolism; Transcription Factors - metabolism

Mitochondrial damage is often both the cause and outcome of cell injury resulting from a variety of toxic insults, hypoxia, or trauma. Increasing mitochondrial biogenesis after renal proximal tubular cell (RPTC) injury accelerated the recovery of mitochondrial and cellular functions (Biochem Biophys...