How comparable are total human chorionic gonadotropin (hCGt) tumour markers assays?

• Published in: Clinical chemistry and laboratory medicine Vol. 58; no. 3; pp. 438 - 444
• Main Authors: Pretorius, Carel J., du Toit, Stephen, Wilgen, Urs, Klingberg, Sandra, Jones, Mark, Ungerer, Jacobus P.J., Tate, Jillian R.
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.03.2020; Walter De Gruyter & Company
• Subjects: Assaying; biomarker; Biomarkers, Tumor - blood; Blood Chemical Analysis - standards; Chorionic gonadotropin; Chorionic Gonadotropin - blood; Confidence intervals; Decisions; Female; Females; Gonadotropins; Humans; Limit of Detection; Male; Males; Malignancy; Markers; oncology; Outliers (statistics); Pituitary (anterior); Pregnancy; Reference Standards; Regression Analysis; Statistical analysis; Tumors; tumour marker; tumour marker; chorionic gonadotropin; biomarker; oncology

Background Total human chorionic gonadotropin (hCGt) tumour marker testing is regarded as an "off label" application for most commercial methods. We compared four assays in patients with a hCGt tumour marker request. We hypothesised that regression slopes would be altered and that outliers...