Insomnia patients have a poor intestinal prognosis: Accompanied by microbiota-derived short chain fatty acids, diet and zonulin

• Published in: Journal of psychiatric research Vol. 183; pp. 25 - 30
• Main Authors: Yerlikaya, Fatma Hümeyra, Onmaz, Duygu Eryavuz, Selvi, Yavuz, Topkafa, Mustafa, Sivrikaya, Abdullah, Kaya, Samet, Akdağ, Fadime
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2025
• Subjects: Adult; BDNF; Brain-Derived Neurotrophic Factor - blood; Cholera Toxin - blood; Diet; Disks Large Homolog 4 Protein - blood; Fatty Acids, Volatile - metabolism; Feces - chemistry; Female; Gastrointestinal Microbiome - physiology; Haptoglobins; Humans; Insomnia; ISI; Male; Middle Aged; Prognosis; Protein Precursors - blood; PSD-95; PSQI; Short chain fatty acid; Sleep Initiation and Maintenance Disorders - blood; Sleep Initiation and Maintenance Disorders - diagnosis; Sleep Initiation and Maintenance Disorders - metabolism; Sleep Initiation and Maintenance Disorders - microbiology; SYPL1 protein; Zonulin; Short chain fatty acid; SYPL1 protein; Insomnia; BDNF; Zonulin; PSD-95; PSQI; ISI

It is becoming increasingly clear that the relationship between sleep disturbance and gut microbiota metabolites is of great importance. This study aimed to examine the changes in microbiota metabolites, brain-derived neurotrophic factors and synaptic proteins in insomnia patients, with a particular...