Herpes simplex virus-1 infection or Simian virus 40-mediated immortalization of corneal cells causes permanent translocation of NLRP3 to the nuclei

• Published in: International journal of ophthalmology Vol. 8; no. 1; pp. 46 - 51
• Main Authors: Wang, Shu-Long, Zhao, Ge, Zhu, Wei, Dong, Xiao-Meng, Liu, Ting, Li, Yuan-Yuan, Song, Wen-Gang, Wang, Yi-Qiang
• Format: Journal Article
• Language: English
• Published: China International Journal of Ophthalmology Press 18.02.2015; Press of International Journal of Ophthalmology (IJO PRESS)
• Subjects: Basic Research; cell; containing; corneal; epithelial; gene; herpes; herpes simplex virus-1; human; human corneal epithelial cell; immortalization; inflammasome; keratitis; pyrin; pyrin containing 3 gene; Simian; Simian vacuolating virus 40; simplex; translocation; vacuolating; virus; virus-1; keratitis; human corneal epithelial cell; translocation; Simian vacuolating virus 40; herpes simplex virus-1; immortalization; inflammasome; pyrin containing 3 gene

AIM: To investigate into the potential involvement of pyrin containing 3 gene(NLRP3), a member of the nucleotide-binding oligomerization domain-like receptors with cytosolic pattern recognition, in the host defense of corneas against viruses.METHODS: The herpes viral keratitis model was utilized in...