Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons

• Published in: Molecular therapy Vol. 11; no. 6; pp. 916 - 925
• Main Authors: Blesch, Armin, Conner, James, Pfeifer, Alexander, Gasmi, Mehdi, Ramirez, Anthony, Britton, William, Alfa, Ron, Verma, Inder, Tuszynski, Mark H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.06.2005
• Subjects: Animals; Cell Survival; Cholinergic Fibers - metabolism; Doxycycline - pharmacology; Female; Fibroblasts; Gene expression; Gene Expression Regulation; Gene therapy; Gene Transfer Techniques; Genetic Vectors - genetics; Growth factors; Lentivirus - genetics; Nerve Growth Factor - genetics; Neurons; Neurons - cytology; Neurons - metabolism; Promoter Regions, Genetic - drug effects; Promoter Regions, Genetic - genetics; Proteins; Rats; Ribonucleic acid; RNA; Septum of Brain - cytology; Septum of Brain - metabolism; Vectors (Biology); La Jolla California; United States > US

Nerve growth factor (NGF) has been shown to promote survival and function of cholinergic neurons in the basal forebrain in various models of neuronal degeneration in rodents and primates. We examined whether a regulatable in vivo expression system can control the survival of cholinergic neurons afte...